Platelet-Rich Plasma (PRP) therapy for mild stress urinary incontinence (grade I) involves injecting an autologous platelet concentrate into the area around the urethral sphincter. Clinical studies indicate that such an injection increases urethral closure pressure and reduces the number of leakage episodes, with effects lasting from several months up to over a year. The procedure is performed under local anesthesia, and the patient can return to normal daily activities the same day, with the exception of avoiding strenuous exercise for 24 hours.
Stress urinary incontinence (SUI) is characterized by involuntary leakage of urine during activities such as coughing, sneezing, running, or jumping, and affects up to 49% of women. Grade I is defined as leakage occurring only during more intense physical exertion, without the need for high-absorbency pads. The underlying cause is a reduction in urethral closure pressure due to weakened pelvic floor support or sphincter insufficiency.
Before the procedure, it is necessary to rule out urinary tract infection, pregnancy, coagulation disorders, and the use of anticoagulant medication.
Follow-up studies have shown that 71% of patients experienced a ≥50% reduction in leakage episodes after a single PRP injection, while 21% achieved complete control. A 2023 meta-analysis demonstrated a significant reduction of 4–6 points in the ICIQ-UI-SF score, with minimal adverse effects. The effectiveness lasts for 6–12 months, and repeating the procedure after one year is recommended to maintain results.
Platelet-rich plasma is an autologous material, obtained from the patient’s own blood, which means the risk of immune reactions or infection is minimal. The most commonly observed effects are transient urethral discomfort and mild hematuria, which usually resolve within 24 hours. Clinical studies have reported no serious adverse events or disturbances in urination.
The patient may walk and perform light activities immediately after leaving the clinic. During the first 24 hours, sports and heavy lifting should be avoided. Sexual activity and pelvic floor muscle training may be resumed after 72 hours.
Platelet-rich plasma (PRP) offers a biological alternative to surgical and pharmacological methods in the treatment of mild stress urinary incontinence (grade I). The therapy is performed on an outpatient basis and allows patients to return to normal daily activities within 24 hours. Schedule a consultation before the procedure.